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This direct demonstration of a role for NKCC1 in vascular effects confirms earlier notions based on isoform expression patterns that the vascular actions of loop diuretics are caused by NKCC1 inhibition 1 where can i get clomiphene citrate Purpose To determine the incidence of second malignancies among patients with Hodgkin s lymphoma HL treated with autologous hematopoietic stem cell transplantation AHSCT compared with patients receiving conventional therapy alone and to identify potential risk factors for their occurrence Patients and Methods We analyzed data on 1, 732 consecutive patients with HL treated at the British Columbia Cancer Agency from 1976 to 2001, including 202 patients undergoing AHSCT The median follow up duration was 9 8 years for the whole cohort, 9 7 years for those patients treated with conventional therapy, and 7 8 years from AHSCT Results The cumulative incidence of developing any second malignancy 15 years after therapy for HL was 9 risk ratio 3